Many guidelines have been developed for the management of sepsis in children and adults. These guidelines emphasize early detection and aggressive management of patients with sepsis to improve outcomes. However, the circumstances in which the guidelines are intended to be used are important and can greatly affect their successful implementation. Therefore, in an attempt to create a sepsis policy that is relevant to both resource-poor and resource-rich environments, the resource levels of different environments are taken into account, and policies that cater to both resource-rich and poor regions of the world. has been formulated. The Pediatric Sepsis Guidelines are designed to address both the resources and capacities of countries with different under-five mortality rates, with monitoring and treatment resources from district hospitals to tertiary care facilities. Additionally, since the final version in 2008, significant efforts have been expended to revise the Surviving Sepsis Campaign guidelines to include new evidence. While these efforts are laudable, adherence to these guidelines has yielded mixed results in both resource-poor and rich regions. Resources are therefore important for policy implementation, but factors other than resources can also hinder successful deployment. This manuscript addresses some of these issues. We review the benefits of adhering to sepsis guidelines, our published experience with compliance, the reasons for poor compliance, and some potential solutions to improve compliance and ultimately improve patient outcomes. Sepsis is a clinical syndrome characterized by systemic inflammation due to infection. There is a range of severity, from sepsis to septic shock. Mortality is highly dependent on the population studied, but mortality in the presence of shock has been estimated at over 10% and over 40% for him. Management of sepsis and septic shock is discussed in this topic overview. Our approach is in line with the guidelines of the 2021 Surviving Sepsis Campaign. We use the Society for Critical Care Medicine (SCCM)/European Society for Intensive Care Medicine (ESICM) definitions, but such definitions are not unanimously accepted. For example, the Centers for Medicare and Medicaid Services (CMS) continue to support the previous definitions of systemic inflammatory response syndrome, sepsis, and severe sepsis. Furthermore, the Infectious Disease Society of America (IDSA) states that the use of such a definition may save lives in patients in shock, while leading to overtreatment of patients with mild variants of sepsis with broad-spectrum antibiotics. I advise that there is The definition, diagnosis, pathophysiology, investigational treatment of sepsis, and management of sepsis in patients with asplenia are discussed separately. "Sepsis Syndrome in Adults: Epidemiology, definition, clinical manifestations, diagnosis and prognosis” and “Pathophysiology of sepsis” and “Investigative and ineffective treatment of sepsis” and “Clinical features, evaluation and management of fever in patients with splenic dysfunction”. All sepsis patients with indications for oxygenation should be given supplemental oxygen and oxygenation should be monitored continuously by pulse oximetry. The ideal target value for peripheral satiety is unknown, but a value of 90-96% is usually aimed for. When encephalopathy and decreased level of consciousness often exacerbate sepsis, requiring intubation and mechanical ventilation to support the increased work of breathing often associated with sepsis or to protect the airway there is.